Enzyme Catalyzed Decomposition of 4-Hydroxycyclophosphamide
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چکیده
منابع مشابه
Enzyme Catalyzed Decomposition of 4-Hydroxycyclophosphamide
According to general doctrine [1] canceroselectivity of Cyclophosphamide is based on different activities of the 4hydroxycyclophosphamide (OHCP) detoxifying cellular enzyme aldehyde dehydrogenase in tumor and normal cells. Aldehyde dehydrogenase converts the OHCP tautomere aldophosphamide (ALDO) to the non-cytotoxic carboxyphosphamide. Due to different activities of the detoxifying enzyme more ...
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ژورنال
عنوان ژورنال: The Open Conference Proceedings Journal
سال: 2017
ISSN: 2210-2892
DOI: 10.2174/2210289201708010044